GC Maff #EffectiveCancerTreatment #BannedbyBigPharma








David Noakes and Lyn Thyer are being persecuted by Big Pharma for developing & producing an EXTREMELY EFFECTIVE CANCER TREATMENT … This is THEIR STORY!




user profile image
TonefreqhzJust now

web site on IPFS

To View the unblocked uncensorable web site install the IPFS browser App.
Download the latest release

Mac – ipfs-desktop-0.7.2.dmg
Windows – ipfs-desktop-setup-0.7.2.exe
Linux – ipfs-desktop-0.7.2-x86_64.AppImage
or see the install section for more options.

IPFS Desktop

Legacy Web site https://gcmaf.se/



From Wikipedia, the free encyclopedia

Jump to navigationJump to search

GcMAF (or Gc protein-derived macrophage activating factor) is a protein produced by modification of vitamin D-binding protein.[1]

GcMAF has not been properly studied in clinical trials and its laboratory results still need to be confirmed independently. So far, all claims on the efficacy of this product have no solid scientific basis. Its marketing is illegal; therefore there is no controlled guarantee on the quality of the product for human consumption sold over the internet.

Public warning issued by the Anticancer Fund[2]

Biochemically, GcMAF results from sequential deglycosylation of the vitamin D-binding protein (the Gc protein), which is naturally promoted by lymphocytes (B and T cells).[3] The resulting protein may be a macrophage activating factor (MAF).[3]MAFs are lymphokines that control the expression of antigens on the surface of macrophages, and one of their functions is to make macrophages become cytotoxic to tumors.[4]

False cancer-curing claims[edit]

Starting around 2008, GcMAF has been promoted as a cure for cancer,[5] HIV,[6] autism[7] and other conditions.[8]

Three out of four of the original studies authored by Yamamoto (published between 2007 and 2009) were retracted by the scientific journals in which they were published in 2014, officially due to irregularities in the way ethical approval was granted.[6][9][10][11] Retraction reasons also included methodological errors in the studies.[12][13] The integrity of the research, conducted by Nobuto Yamamoto and colleagues, that originally prompted claims regarding cancer and HIV has been questioned.[5][2]

The UK Medicines and Healthcare products Regulatory Agency[8] and Cancer Research UK has warned the public about spurious claims of clinical benefits, misleadingly based on reduced levels of the alpha-N-acetylgalactosaminidase enzyme (also known as nagalase), whose production might be increased in many cancers.[5]

In 2014 the Belgian Anticancer Fund has communicated serious concerns about published studies on GcMAF by Yamamoto and colleagues.[2]

In 2015 the UK Medicines and Healthcare products Regulatory Agency (MHRA) closed a factory in Milton, Cambridgeshire owned by David Noakes‘ company Immuno Biotech manufacturing GcMAF for cancer treatment.[14] In September 2018 Noakes pleaded guilty to manufacturing a medicinal product without a manufacturer’s licence, selling or supplying medicinal products without market authorisation, and money laundering.[15]

As of 2014 an Israeli company called Efranat was running a clinical trial of GcMAF in people with various kinds of cancer at a hospital in Israel.[16] As of December 2017 Efranet had obtained an orphan designation from the FDA for use of GcMAF in recurrent respiratory papillomatosis[17] and said that it was conducting a Phase I trial in Israel.[18]

See also[edit]


  1. ^ Galactosidases — Advances in Research and Application. Scholarly Editions. 21 June 2013. p. 52. ISBN 978-1-4816-8801-7.
  2. Jump up to:a b c “GCMAF”. Anticancer Fund. 24 July 2014. Retrieved 2014-07-26.
  3. Jump up to:a b Malik, Suneil; Fu, Lei; Juras, David James; Karmali, Mohamed; Wong, Betty Y. L.; Gozdzik, Agnes; Cole, David E. C. (January–February 2013). “Common variants of the vitamin D binding protein gene and adverse health outcomes”Critical Reviews in Clinical Laboratory Sciences50 (1): 1–22. doi:10.3109/10408363.2012.750262PMC 3613945PMID 23427793.
  4. ^ Mosser, David M. (February 2003). “The many faces of macrophage activation”. Journal of Leukocyte Biology73 (2): 209–212. doi:10.1189/jlb.0602325PMID 12554797.
  5. Jump up to:a b c Arney, Kat (3 December 2008). Cancer cured for good?’ – Gc-MAF and the miracle cure (revised 25 July 2014)”Cancer Research UK. Retrieved 10 February 2015.
  6. Jump up to:a b (Retracted) Yamamoto, Nobuto; Ushijima, Naofumi; Koga, Yoshihiko (January 2009). “Immunotherapy of HIV-infected patients with Gc protein-derived macrophage activating factor (GcMAF)”. Journal of Medical Virology81 (1): 16–26. doi:10.1002/jmv.21376PMID 19031451.
  7. ^ Miller, Michael E. (16 July 2015). “The mysterious death of a doctor who peddled autism ‘cures’ to thousands”Washington Post. Retrieved 26 August 2015.
  8. Jump up to:a b “Press Release: Regulator warns against GcMAF made in unlicensed facility in Cambridgeshire – GOV.UK”. Medicines and Healthcare products Regulatory Agency. 3 February 2015.
  9. ^ (Retracted) Yamamoto, Nobuto; Suyama, Hirofumi; Yamamoto, Nobuyuki; Ushijima, Naofumi (15 January 2008). “Immunotherapy of metastatic breast cancer patients with vitamin D-binding protein-derived macrophage activating factor (GcMAF)”. International Journal of Cancer122 (2): 461–467. doi:10.1002/ijc.23107PMID 17935130.
  10. ^ Yamamoto, N.; Suyama, H.; Nakazato, H.; Yamamoto, N.; Koga, Y. (2014). “Retraction Note to: Immunotherapy of metastatic colorectal cancer with vitamin D-binding protein-derived macrophage-activating factor, GcMAF”. Cancer Immunology, Immunotherapy63 (12): 1349. doi:10.1007/s00262-014-1616-xPMID 25297451.
  11. ^ “Retraction”. International Journal of Cancer135 (6): 1509. 15 September 2014. doi:10.1002/ijc.29014.
  12. ^ Ivan Oransky (25 July 2014). “Paper about widely touted but unapproved “cure” for cancer, autism retracted”. Retractionwatch.
  13. ^ “Tracking retractions as a window into the scientific process Yet another study of widely touted cancer “cure” retracted”Retraction Watch. Retraction Watch. 2014-10-10. Retrieved 28 July 2015.
  14. ^ UK’s MHRA shuts down GcMAF plant (FDA News website)
  15. ^ Mann, Nick. “Man behind GcMAF is facing jail”. Retrieved 2018-09-30.
  16. ^ Cancer treatment developer Efranat raises $4.5 million, November 18, 2014 (Globes)
  17. ^ “Orphan Drug Designation – Modified vitamin D binding protein”. FDA. Retrieved 13 December 2017.
  18. ^ “Vitamin D binding protein macrophage-activating factor”. AdisInsight. Retrieved 7 September 2017.

Further reading[edit]


Author: rogerglewis

https://about.me/rogerlewis Looking for a Job either in Sweden or UK. Freelance, startups, will turń my hand to anything.

4 thoughts on “GC Maff #EffectiveCancerTreatment #BannedbyBigPharma

Leave a Reply